The Ford F-Series is a series of light-duty trucks and medium-duty trucks (Class 2-7) that have been marketed and manufactured by Ford Motor Company since 1948. The Ford F-150 is the best-selling vehicle in the United States. The Ford F-250 is the best-selling heavy-duty truck in the United States.
The Ford F150 is the clear winner in this matchup. It has a longer wheelbase, more horsepower, and more torque than the Ford F250. It is also lighter and more fuel efficient.