The Ford F-250 and Ford F-350 are both full-size pickup trucks that have been in production since the 1950s. The F-250 is the smaller of the two, while the F-350 is the larger. Both trucks are built on the same platform and share many of the same features, but the F-350 is typically more powerful and has a higher payload capacity.
The Ford F250 is the winner in this comparison. It has a better fuel economy, making it more affordable to operate. It also has a higher payload capacity, making it more capable for heavy-duty tasks.