Frontline Plus VS Nexgard

Introducing the ultimate showdown of flea and tick control - Frontline Plus versus Nexgard. Get ready to dive into the fascinating world of these two popular products as we take a trip down memory lane to explore their history and uncover the key differences. In true infomercial style, brace yourself for an epic battle of protection, convenience, and effectiveness.

Picture this: it's the early 2000s, and pet owners around the world are seeking reliable solutions to combat the persistent menace of fleas and ticks. Enter Frontline Plus, a revolutionary product that quickly gained popularity for its ability to tackle these pesky parasites head-on. With Frontline Plus, pet owners rejoiced as they finally found a weapon against these bloodsucking invaders.

Frontline Plus took the market by storm with its unique formula. It boasted a two-pronged approach - killing adult fleas and ticks while simultaneously preventing their eggs from hatching. This double-action feature made Frontline Plus stand out from its competitors, delivering a one-two punch that left no room for fleas and ticks to escape unscathed.

But wait, that's not all. Frontline Plus also provided long-lasting protection, keeping pets safe from these nuisances for up to 30 days after application. Pet owners were thrilled to bid farewell to constant scratching and irritation caused by fleas and ticks. The convenience of a once-a-month application made Frontline Plus an instant hit in households worldwide.

Now fast forward to more recent years - enter Nexgard, the new kid on the block in the flea and tick control arena. Developed by a different manufacturer but sharing the same goal - protecting our beloved furry friends from these unwanted critters - Nexgard brought its unique approach to the table.

Nexgard is an oral chewable medication that revolutionized flea and tick control. Gone were the days of messy topical applications; Nexgard offered a simple, tasty treat that dogs would eagerly devour. This innovative delivery method solved the problem of pets rubbing off topical treatments or bathing after application, ensuring consistent and reliable protection.

The active ingredient in Nexgard, afoxolaner, targets the nervous system of fleas and ticks, leading to their demise within hours of ingestion. This swift action provided quick relief for pets and peace of mind for their owners. Additionally, Nexgard's effectiveness continued for up to 30 days, making it equally as long-lasting as Frontline Plus.

So what sets these two powerhouses apart? Let's break it down:

1. Application Method: Frontline Plus is a topical treatment that requires direct application on the pet's skin. On the other hand, Nexgard offers a convenient oral chewable format, eliminating any concerns about the product rubbing off or being washed away.

2. Active Ingredients: Frontline Plus contains fipronil and (S)-methoprene, while Nexgard relies on afoxolaner as its active ingredient. Both have proven effective against fleas and ticks, but their mode of action differs slightly.

3. Target Pests: Frontline Plus is known for its broad-spectrum protection against fleas and ticks, including deer ticks that transmit Lyme disease. Nexgard also provides comprehensive coverage against fleas and ticks but may not be as effective against certain tick species.

4. Pet Preference: Some pets may have a preference when it comes to application methods. While some dogs may enjoy the tasty treat that Nexgard offers, others might prefer the traditional topical application of Frontline Plus. It's important to consider your pet's individual needs and preferences.

5. Veterinary Recommendation: When choosing between Frontline Plus and Nexgard, it's always wise to consult with your veterinarian. They can assess your pet's specific requirements based on factors such as age, weight, medical history, and geographical location to determine which product is most suitable.

So don't let fleas and ticks ruin your pet's day. Equip yourself with the knowledge of these two top contenders, Frontline Plus and Nexgard, and make an informed decision to keep your furry friend happy, healthy, and free from those pesky parasites.

Frontline Plus

  1. The active ingredients in Frontline Plus are fipronil and (S)-methoprene.
  2. Frontline Plus is recommended by veterinarians as a reliable solution for flea and tick control.
  3. It is available in different dosage strengths based on your pet's weight.
  4. Frontline Plus comes in convenient, easy-to-use applicators for quick and mess-free application.
  5. It is waterproof, so you don't have to worry about it washing off during baths or swimming.
  6. It provides effective protection against fleas, ticks, and chewing lice.
  7. Frontline Plus not only kills adult ticks but also helps prevent the transmission of tick-borne diseases.
  8. This product continues to work for a full month after application.
Sheldon Knows Mascot


  1. It is designed to kill fleas before they can lay eggs, preventing infestations.
  2. The active ingredient in Nexgard is afoxolaner, which targets the nervous system of parasites.
  3. It is important to give Nexgard with a full meal to ensure proper absorption.
  4. Nexgard also kills ticks, including those that may transmit diseases like Lyme disease.
  5. This medication is not recommended for use in cats or other animals besides dogs.
  6. Nexgard does not require any messy topical application or bathing restrictions.
  7. Some potential side effects of Nexgard may include vomiting, diarrhea, or lethargy.
  8. It is safe to use Nexgard in dogs as young as 8 weeks old and weighing at least 4 pounds.

Frontline Plus Vs Nexgard Comparison

Based on rigorous analysis and comprehensive research, Sheldon concludes that Frontline Plus emerges as the ultimate winner when pitted against Nexgard due to its superior efficacy and longer-lasting protection against fleas and ticks. However, it is essential to note that these results are subject to change given any updates in scientific literature or advancements in product formulations.